eleveld_pk: Eleveld et al. pharmacokinetic data

In tci: Target Controlled Infusion (TCI)

Eleveld et al. pharmacokinetic data

Description

Empirical Bayes (EB) estimates of PK parameters for the Eleveld et al. (2018) PK-PD model. EB estimates were calculated using the PK-PD datasets and NONMEM files provided by Eleveled et al. (2018). The original datasets were obtained through the Open TCI Initiative website (opentci.org) and based on contributions from a number of researchers who made their datasets publically available.

Usage

data(eleveld_pk)

Format

A data frame with 1033 rows and 16 variables:

ID

Patient ID

V1

EB estimate of first compartment volume

V2

EB estimate of second compartment volume

V3

EB estimate of third compartment volume

CL

EB estimate of clearance for the first compartment

Q2

EB estimate of inter-compartmental clearance for second compartment

Q3

EB estimate of inter-compartmental clearance for third compartment

AGE

Patient's age (years)

WGT

Patient's weight (kg)

HGT

Patient's height (cm)

M1F2

Patient's sex: male = 1, female = 2

PMA

Patient's post-menstrual age. Assumed to be age + 40 weeks if not provided

TECH

Presence of concomitant anaesthetic techniques (Local anesthetic = 1, Opioids = 2)

BMI

Patient's BMI

FFM

Patient's fat-free mass (FFM)

A1V2

Sampling site: arterial sampling = 1, venous sampling = 2

References

Eleveld et al. (2018) British Journal of Anesthesia Vol. 120, 5:942-959 (BJA)

tci documentation built on Aug. 15, 2022, 9:09 a.m.