pkmod_minto: Minto population PK model for remifentanil

In tci: Target Controlled Infusion (TCI)

Minto population PK model for remifentanil

Description

Evaluate Minto population PK model at patient covariate values. Published in Minto et al. (1997). "Influence of Age and Gender on the Pharmacokinetics and Pharmacodynamics of Remifentanil: I. Model Development." Anesthesiology 86:10-23 doi: https://doi.org/10.1097/00000542-199701000-00004. Residual error standard deviations are taken from Eleveld et al. (2017). "An Allometric Model of Remifentanil Pharmacokinetics and Pharmacodynamics." Anesthesiology Vol. 126, 1005–1018 doi: https://doi.org/10.1097/ALN.0000000000001634.

Usage

pkmod_minto(
  AGE,
  HGT = NULL,
  TBW = NULL,
  MALE = NULL,
  LBM = NULL,
  PD = TRUE,
  ...
)

Arguments

AGE	Age (years)
HGT	Height (cm). Used to calculate LBM if LBM is not provided.
TBW	Weight (kg). Used to calculate LBM if LBM is not provided.
MALE	Logical. Used to calculate LBM if LBM is not provided.
LBM	Lean body mass (kg). Can be provided instead of TBW, HGT, and MALE
PD	Logical. Should PD parameters be returned in addition to PK parameters.
...	Arguments passed to 'pkmod'

Value

'pkmod' object with Schnider population PK parameters

Examples

pkmod_minto(AGE = 40,HGT=170,LBM = 43.9)
pkmod_minto(AGE = 40,HGT=170,TBW=50,MALE=TRUE)

tci documentation built on Aug. 15, 2022, 9:09 a.m.