pkmod3cpt: Three compartment IV infusion with first-order elimination.

In tci: Target Controlled Infusion (TCI)

Three compartment IV infusion with first-order elimination.

Description

Three compartment IV infusion with first-order elimination. Elimination is assumed to occur only from central compartment if 'k20', 'k30' are not specified.

Usage

pkmod3cpt(tm, kR, pars, init = c(0, 0, 0))

Arguments

tm	Vector of times to evaluate the PK function at
kR	Infusion rate (e.g. ml/min).
pars	Named vector of parameters with names ('K10','K12','K21','V1','V2') or ('CL','Q','V1','V2').
init	Initial concentration. Defaults to 0 in all compartments.

Value

Numeric matrix of concentrations for a constant infusion rate

Examples

pkmod3cpt(1,1,c(CL = 15, Q2 = 10, Q3 = 5, V1 = 10, V2 = 20, V3 = 50))

tci documentation built on Aug. 15, 2022, 9:09 a.m.