topologyGSA: Gene Set Analysis Exploiting Pathway Topology

Using Gaussian graphical models we propose a novel approach to perform pathway analysis using gene expression. Given the structure of a graph (a pathway) we introduce two statistical tests to compare the mean and the concentration matrices between two groups. Specifically, these tests can be performed on the graph and on its connected components (cliques).

Getting started

Package details

AuthorSofia Massa, Gabriele Sales
MaintainerGabriele Sales <>
Package repositoryView on CRAN
Installation Install the latest version of this package by entering the following in R:

Try the topologyGSA package in your browser

Any scripts or data that you put into this service are public.

topologyGSA documentation built on July 7, 2021, 5:06 p.m.