dag_bcell: DAG representation of the B cell receptor signaling pathway

Description

Description

The B cell receptor signaling pathway (BCR) converted to a DAG. In case of nodes with multiple genes, the most differentially expressed between groups of patients defined in y1 (acute lymphocytic leukemia patients with BCR/ABL gene rearrangement) and y2 (acute lymphocytic leukemia patients with BCR/ABL gene rearrangement) matrices.

Chiaretti S., Li X., Gentleman R., Vitale A., Wang K.S., Mandelli F., Fo R., Ritz J. (2005) Gene expression profiles of B-lineage adult acute lymphocytic leukemia reveal genetic patterns that identify lineage derivation and distinct mechanisms of transformation. Clin Cancer Res, 11:7209-7219. http://clincancerres.aacrjournals.org/content/11/20/7209.long

Massa, M.S., Chiogna, M., Romualdi, C. (2010). Gene set analysis exploiting the topology of a pathway. BMC Systems Biology, 4:121 http://www.biomedcentral.com/1752-0509/4/121


topologyGSA documentation built on May 2, 2019, 5:56 a.m.