Several distinct genetic mechanisms lead to acute lymphocytic leukemia (ALL) malignant transformations deriving
from distinct lymphoid precursor cells that have been committed to either T-lineage or B-lineage differentiation.
Chromosome translocations and molecular rearrangements are common events in B-lineage ALL and reflect distinct
mechanisms of transformation. The B cell Receptor (BCR/ABL) gene rearrangement occurs in about 25% of cases in
adult ALL, and much less frequently in pediatric ALL.
y2 dataset contains gene expression signatures of BCR signaling pathway (composed by 35 gene products, n.columns = 35)
in acute lymphocytic leukemia (ALL) cells not associated with BCR/ABL gene rearrangement (n. rows = 41).
Expression values are normalized according to
Chiaretti S., Li X., Gentleman R., Vitale A., Wang K.S., Mandelli F., Fo R., Ritz J. (2005) Gene expression profiles of B-lineage adult acute lymphocytic leukemia reveal genetic patterns that identify lineage derivation and distinct mechanisms of transformation. Clin Cancer Res, 11:7209-7219. http://clincancerres.aacrjournals.org/content/11/20/7209.long
Massa, M.S., Chiogna, M., Romualdi, C. (2010). Gene set analysis exploiting the topology of a pathway. BMC Systems Biology, 4:121 http://www.biomedcentral.com/1752-0509/4/121
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