ttScreening-package: Genome-Wide DNA Methylation Sites Screening by Use of...

Description Details Author(s) References See Also

Description

A screening process to filter out non-informative DNA methylation sites by applying (ordinary or robust) linear regressions to training data, and the results are further examined using testing samples. Surrogate variables are included to account for unknown factors.

Details

Package: ttScreening
Type: Package
Version: 1.6
Date: 2018-09-18
License: Artistic-2.0

This package utilizes training and testing samples to filter out uninformative DNA methylation sites. Surrogate variables (SVs) of DNA methylation are included in the filtering process to explain unknown factor effects.

Author(s)

Meredith Ray, Xin Tong, Hongmei Zhang

Maintainer: Meredith Ray <maray@memphis.edu>

References

Ray MA, Tong X, Lockett GA, Zhang H, and Karmaus WJJ. (2016) “An Efficient Approach to Screening Epigenome-Wide Data”, BioMed Research International.

Leek JT and Storey JD. (2007) “Capturing heterogeneity in gene expression studies by ‘Surrogate Variable Analysis’.” PLoS Genetics, 3: e161.

See Also

sva


ttScreening documentation built on May 2, 2019, 2:51 p.m.