vtPriorPar: Get prior distribution parameters

In visit: Vaccine Phase I Design with Simultaneous Evaluation of Immunogenicity and Toxicity

Get prior distribution parameters

Description

Get prior distribution parameters for partially parametric or partially parametric+ models

Usage

vtPriorPar(prior.y = NULL, tau = NULL, sdalpha = 10, sdrho = 10,
  vtheta = NULL)

Arguments

prior.y	Historical data for generating prior parameters. It has the same structure as obs.y in vtPost.
tau	Vector of \tau values. See visit for details. Can not be NULL if prior.y is NULL.
sdalpha	\sigma_\alpha. See visit for details.
sdrho	\sigma_\rho.
vtheta	Additional variance term for eliciting prior parameters from prior.y

Details

The priors are specified as q^{(l)} \sim Beta(a_q^{(l)}, b_q^{(l)}), and \log\rho^{(l)} \sim N(0, \sigma_\rho^2).

Value

A VTPRIOR list with

• TAU:vector of \tau's for each level

• ABCD:A matrix of 4 columns: a_q, b_q, a_\rho, {\sigma_\rho}. Each row represents a dose level.

Examples

par.prior <- vtPriorPar(tau = c(0.2, 0.4, 0.6), sdalpha = 10);

visit documentation built on Aug. 9, 2023, 5:08 p.m.