Description Details Slots Examples
This class can be used to combine multiple increment rules with the MIN operation.
IncrementsList contains all increment rules, which are again
objects of class Increments. The minimum of these
individual increments is taken to give the final maximum increment.
IncrementsListlist of increment rules
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 | # As example, here we are combining 2 different increment rules.
# The first rule is the following:
# maximum doubling the dose if no DLTs were observed at the current dose
# or maximum increasing the dose by 1.33 if 1 or 2 DLTs were observed at the current dose
# or maximum increasing the dose by 1.22 if 3 or more DLTs were observed
# The second rule is the following:
# maximum doubling the dose if the current dose is <20
# OR only maximum increasing the dose by 1.33 if the current dose is >=20
myIncrements1 <- IncrementsRelativeDLT(DLTintervals = c(0, 1, 3),
increments = c(1, 0.33, 0.2))
myIncrements2 <- IncrementsRelative(intervals=c(0, 20),
increments=c(1, 0.33))
# Now we combine the 2 rules
combIncrement <- IncrementMin(IncrementsList=
list(myIncrements1,myIncrements2))
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