BIMIB-DISCo/LACE: Longitudinal Analysis of Cancer Evolution (LACE)
LACE is an algorithmic framework that processes single-cell somatic mutation profiles from cancer samples collected at different time points and in distinct experimental settings, to produce longitudinal models of cancer evolution. The approach solves a Boolean Matrix Factorization problem with phylogenetic constraints, by maximizing a weighed likelihood function computed on multiple time points.
Getting started
Browse package contents
Package details |
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| Bioconductor views | BiomedicalInformatics SingleCell SomaticMutation |
| Maintainer | |
| License | file LICENSE |
| Version | 2.10.0 |
| URL | https://github.com/BIMIB-DISCo/LACE |
| Package repository | View on GitHub |
| Installation |
Install the latest version of this package by entering the following in R:
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