BIMIB-DISCo/LACE: Longitudinal Analysis of Cancer Evolution (LACE)

LACE is an algorithmic framework that processes single-cell somatic mutation profiles from cancer samples collected at different time points and in distinct experimental settings, to produce longitudinal models of cancer evolution. The approach solves a Boolean Matrix Factorization problem with phylogenetic constraints, by maximizing a weighed likelihood function computed on multiple time points.

Getting started

Package details

Bioconductor views BiomedicalInformatics SingleCell SomaticMutation
Maintainer
Licensefile LICENSE
Version1.4.0
URL https://github.com/BIMIB-DISCo/LACE
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
install.packages("remotes")
remotes::install_github("BIMIB-DISCo/LACE")
BIMIB-DISCo/LACE documentation built on April 29, 2021, 1:04 p.m.