getBinaryMutationData: Compute a binary gene mutation data matrix from SNP and other...

In CBIIT/rcellminer: rcellminer: Molecular Profiles, Drug Response, and Chemical Structures for the NCI-60 Cell Lines

Compute a binary gene mutation data matrix from SNP and other mutation event-level data.

Description

Compute a binary gene mutation data matrix from SNP and other mutation event-level data.

Usage

getBinaryMutationData(
  mutInfo,
  mutData,
  maxVariantFreq = 0.2,
  maxNormalPopulationFreq = 0.005,
  maxSiftScore = 0.05,
  minPolyPhenScore = 0.85
)

Arguments

mutInfo	A data frame with the following named columns: Gene, the name of the gene associated with the mutation event; probe.ids, a unique identifier specifying the mutation event; SNP_1000_genome, the frequency of the mutation event in SNP 1000; ESP5400, the frequency of the mutation event in ESP5400; SNP_type, the type of mutation event, chosen from "MISSENSE", "FRAMESHIFT", "NONFRAMESHIFT", "NONSENSE", "SPLICING"; SIFT_score, the SIFT score; Polyphen_score, the POLYPHEN score. Rownames of mutInfo should be set to probe.ids, i.e., the unique mutation event specifier.
mutData	A matrix with event level mutation information, with SNPs, etc. along rows and samples along columns. Rownames of mutData should exactly match those of mutInfo. The i-th row of mutInfo should thus give detailed information for the mutation event with data specified in the i-th row of mutData.
maxVariantFreq	The maximum proportion of mutant samples (used to exclude frequently occuring events); default value = 0.2.
maxNormalPopulationFreq	The maximum freqency of a mutation in the normal population (used to exclude likely germline variants); default value = 0.005.
maxSiftScore	The maximum accepted SIFT score (used to exclude presumed non-deleterious mutations); default value = 0.05.
minPolyPhenScore	The minimum accepted POLYPHEN score (used to exclude presumed non-deleterious mutations); default value = 0.85.

Value

A binary gene mutation matrix, with genes along rows, samples along columns, and 1s indicating deleterious mutations.

CBIIT/rcellminer documentation built on Aug. 8, 2024, 12:15 p.m.