R/SPsimSeq-package.R

In CenterForStatistics-UGent/SPsimSeq: Semi-parametric simulation tool for bulk and single-cell RNA sequencing data

#' SPsimSeq package
#'
#' SPsimSeq uses a specially designed exponential family for density estimation 
#' to constructs the distribution of gene expression levels from a given real RNA 
#' sequencing data (single-cell or bulk), and subsequently, simulates a new 
#' dataset from the estimated marginal distributions using Gaussian-copulas to 
#' retain the dependence between genes. It allows simulation of multiple 
#' groups and batches with any required sample size and library size.
#'
#' @docType package
#' @author  Alemu Takele Assefa \email{alemutak@hotmail.com}
#' @author Stijn Hawinkel \email{stijnhawinkel@hotmail.com}
#' 
#' @references
#' \itemize{
#' \item Alemu Takele Assefa, Jo Vandesompele, Olivier Thas. (2020). SPsimSeq: semi-parametric simulation of bulk and single cell RNA sequencing data, \emph{Bioinformatics}, , btaa105, https://doi.org/10.1093/bioinformatics/btaa105
#' }
#' @name SPsimSeq-package  
#' 
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