build_domino: Calculate a signaling network for a domino object
In Chris-Cherry/domino: Receptor Ligand Analysis for Single Cell RNA Seq

build_domino

R Documentation

Calculate a signaling network for a domino object

Description

This function calculates a signaling network. It requires a domino object preprocessed from create_domino and returns a domino object prepared for plotting with the various plotting functions in this package.

Usage

build_domino(
  dom,
  max_tf_per_clust = 5,
  min_tf_pval = 0.01,
  max_rec_per_tf = 5,
  rec_tf_cor_threshold = 0.15
)

Arguments

`dom`	Domino object from create_domino.
`max_rec_per_tf`	Maximum number of receptors to link to each transcription factor.
`rec_tf_cor_threshold`	Minimum pearson correlation used to consider a receptor linked with a transcription factor. Increasing this will decrease the number of receptors linked to each transcription factor.