DeltaCI: Computation of confidence intervals for difference in summary...

In HaemAalborg/DoseR: Analysis of dose response experiments

Description

This function is used for calculation of confidence intervals for the difference in summary statistics when the same cell line have been treated with a drug in two conditions.

Usage

DeltaCI(A.data, 
        conf     = c(2.5, 97.5), 
        diff.var = 1, 
        drug     = 1, 
        model    = "G", 
        type     = "AUC", 
        time     = "48",
        dose.scale  = "mol/l",
        dose.logfun = "log10",
        reverse     = FALSE)

Arguments

A.data	The A.data object created by the function doseResponseModel.
conf	Numeric vector indicating the limits of the confidence intercal defaults to c(2.5, 97.5).
diff.var	Character indicating the variable used for separating the experiments for which the difference is to be calculated.
drug	The drug for which the difference should be calculated.
type	The summary statistic for which the difference is to be calculated.
time	The time point where the difference is to be calculated.
dose.scale	Character indicating the scale used for the summary statistcs. The unit is written as e.g. ug/ml to indicate micro grams per milli litre and defaults to mol/l. The unit is written as ug/ml The current implementations for multiples are: Name deca hecto kilo mega giga tera peta exa zetta yotta Prefix da h k M G T P E Z Y Factor 10^0 10^1 10^2 10^3 10^6 10^9 10^12 10^15 10^18 10^21 10^24 The current implementations for fractions are: Name deci centi milli micro nano pico femto atto zepto yocto Prefix d c m u n p f a z y Factor 10^-1 10^-2 10^-3 10^-6 10^-9 10^-12 10^-15 10^-18 10^-21 10^-24
dose.logfun	Character indicating if the concentrations should be log transformed. The possible inputs are nolog for non log transformation, log10, log2, log for log transforming with base 10, 2, and e, respectively.
reverse	Reverse the calculation of difference.

Value

Confidence interval on differences for calculated summary statistics.

Author(s)

The function was written at department of haematology, Aalborg University Hospital and maintained by Steffen Falgreen.

References

Steffen Falgreen et al. Exposure time independent summary statistics for assessment of drug dependent cell line growth inhibition (2013)

See Also

doseResponseModel,DeltaPlot

Examples

require(DoseR)
data(A.data)

HaemAalborg/DoseR documentation built on Jan. 17, 2021, 7:40 a.m.