pk_2cmt_inf_dose_from_cmin: Calculate dose to achieve steady state trough for...

In InsightRX/clinPK: Clinical Pharmacokinetics Toolkit

Calculate dose to achieve steady state trough for 2-compartmental PK model with infusion dosing at steady state

Description

Calculate dose to achieve steady state trough for 2-compartmental PK model with infusion dosing at steady state

Usage

pk_2cmt_inf_dose_from_cmin(
  cmin = 1,
  tau = 12,
  t_inf = 1,
  CL = 3,
  V = 30,
  Q = 2,
  V2 = 20
)

Arguments

cmin	desired trough concentration
tau	dosing interval
t_inf	infusion time
CL	clearance
V	volume of distribution
Q	inter-compartimental clearance
V2	volume of peripheral compartment

Examples

dos <- pk_2cmt_inf_dose_from_cmin(
  cmin = 10, tau = 12, t_inf = 2,
  CL = 5, V = 50, Q = 20, V2 = 200)
find_nearest_dose(dos, 100)

InsightRX/clinPK documentation built on Feb. 28, 2024, 12:06 a.m.