Description Usage Arguments Details Value
Function calculate DIAS score from signature using global density method.
1 | global_density(signature, oligos = NULL, alpha = c(0.05, 0.025, 0.01))
|
signature |
signature from |
oligos |
either numeric vector or character vector of oligonucleotides that will be used. If not specified, whole signature is used. |
alpha |
significance level of scoring intervals. |
First, signature is filtered and quality
is removed. If oligos
were specified, only specified oligos (either columns, if oligos
was
numeric vector, or specific oligonucleotides, if oligos
was character
vector) are kept. Then global density for all retained oligonucleotide is
calculated and each window of signature is scored if it falls to confidence
interval defined by alpha. Then all DIAS from all oligonucleotides are
summed and final DIAS is returned.
DIAS score for given signature.
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