escoEstDropout: Estimate esco dropout parameters

Description Usage Arguments Details Value

View source: R/esco-estimate.R

Description

Estimate the midpoint and shape parameters for the logistic function used when simulating dropout.

Usage

1
escoEstDropout(norm.counts, params)

Arguments

norm.counts

library size normalised counts matrix.

params

escoParams object to store estimated values in.

Details

Logistic function parameters are estimated by fitting a logistic function to the relationship between log2 mean gene expression and the proportion of zeros in each gene. See nls for details of fitting. Note this is done on the experiment level.

Value

escoParams object with estimated values.


JINJINT/ESCO documentation built on May 13, 2021, 7:25 p.m.