EpiCluster is a dimensional reduction and clustering algorithm specifically designed for large DNA methylation datasets, e.g. EpigenomeWide Association Studies (EWAS). The method is based on a variational Bayes nonnegative matrix factorization (NMF) method, which preserves the bounded betavalued nature of DNA methylation data. This NMF method is used for dimensional reduction and can be used in conjunction with the RPBMM algorithm. Users can used the algorithm for (i) dimensional reduction and inference of components of variation, (ii) for unsupervised clustering and for (iii) feature selection.
Package details 


Author  Yuan Tian [cre,aut], Andrew E Teschendorff [cre], Zhanyu Ma [cre] 
Bioconductor views  DimensionReduction FeatureExtraction MethylationArray Microarray 
Maintainer  Yuan Tian <[email protected]> 
License  GPL (>=2.00) 
Version  0.99.0 
Package repository  View on GitHub 
Installation 
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