Description Usage Arguments Value
Effect size is measures as the fraction of sample/patient cancers with a non-silent mutation in a driver gene above the background mutation rate.
1 2 | ratiometricBbdRequiredSampleSize(p, cv, desired.power, possible.samp.sizes, mu,
effect.size, Df = 1, signif.lvl = 5e-06, Leff = 1500 * 3/4)
|
p |
the background fraction of total mutations represented by the ratio-metric feature (e.g. inactivating mutations / total) |
cv |
the coefficient of variation for the parameter p |
desired.power |
A floating point number indicating desired power |
possible.samp.sizes |
vector of possible number of cancer samples in study |
mu |
mutation rate per base |
effect.size |
fraction of samples above background mutation rate |
Df |
fraction of driver mutations that are the specific one of interest |
signif.lvl |
significance level for binomial test |
Leff |
effective gene length of CDS in bases for an average gene |
List containing the smallest effect size with sufficient power
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