Description Usage Arguments Value
Effect size is measures as the fraction of sample/patient cancers with a non-silent mutation in a driver gene above the background mutation rate.
1 2 | smgBbdRequiredSampleSize(desired.power, mu, cv, possible.samp.sizes,
effect.size, signif.level = 5e-06, Leff = 1500 * 3/4)
|
desired.power |
A floating point number indicating desired power |
mu |
Mutation rate per base |
cv |
Coefficient of Variation surrounding the uncertaintly in mutation rate |
possible.samp.sizes |
vector of possible number of cancer samples in study |
effect.size |
fraction of samples above background mutation rate |
signif.level |
significance level for binomial test |
Leff |
effective gene length of CDS in bases for an average gene |
List containing the smallest effect size with sufficient power
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