EmpiricalCalibration-package: EmpiricalCalibration: Routines for Performing Empirical...

In OHDSI/EmpiricalCalibration: Routines for Performing Empirical Calibration of Observational Study Estimates

EmpiricalCalibration: Routines for Performing Empirical Calibration of Observational Study Estimates

Description

Routines for performing empirical calibration of observational study estimates. By using a set of negative control hypotheses we can estimate the empirical null distribution of a particular observational study setup. This empirical null distribution can be used to compute a calibrated p-value, which reflects the probability of observing an estimated effect size when the null hypothesis is true taking both random and systematic error into account. A similar approach can be used to calibrate confidence intervals, using both negative and positive controls. For more details, see Schuemie et al. (2013) \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1002/sim.5925")} and Schuemie et al. (2018) \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1073/pnas.1708282114")}.

Author(s)

Maintainer: Martijn Schuemie [e-mail] (ORCID)

Authors:

• Marc Suchard (ORCID)

See Also

Useful links:

• https://ohdsi.github.io/EmpiricalCalibration/

• https://github.com/OHDSI/EmpiricalCalibration

• Report bugs at https://github.com/OHDSI/EmpiricalCalibration/issues

OHDSI/EmpiricalCalibration documentation built on Jan. 31, 2024, 7:29 p.m.