createSimulationSettings: Create simulation settings

In OHDSI/EvidenceSynthesis: Synthesizing Causal Evidence in a Distributed Research Network

Create simulation settings

Description

Create an object specifying a simulation. Currently only Cox proportional hazard models are supported.

Usage

createSimulationSettings(
  nSites = 5,
  n = 10000,
  treatedFraction = 0.2,
  nStrata = 10,
  minBackgroundHazard = 2e-07,
  maxBackgroundHazard = 2e-05,
  hazardRatio = 2,
  randomEffectSd = 0
)

Arguments

nSites	Number of database sites to simulate.
n	Number of subjects per site. Either a single number, or a vector of length nSites.
treatedFraction	Fraction of subjects that is treated. Either a single number, or a vector of length nSites.
nStrata	Number of strata per site. Either a single number, or a vector of length nSites.
minBackgroundHazard	Minimum background hazard. Either a single number, or a vector of length nSites.
maxBackgroundHazard	Maximum background hazard. Either a single number, or a vector of length nSites.
hazardRatio	Hazard ratio.
randomEffectSd	Standard deviation of the log(hazardRatio). Fixed effect if equal to 0.

Value

An object of type simulationSettings, to be used in the simulatePopulations() function.

See Also

simulatePopulations

Examples

settings <- createSimulationSettings(nSites = 1, hazardRatio = 2)
populations <- simulatePopulations(settings)

# Fit a Cox regression for the simulated data site:
cyclopsData <- Cyclops::createCyclopsData(Surv(time, y) ~ x + strata(stratumId),
  data = populations[[1]],
  modelType = "cox"
)
cyclopsFit <- Cyclops::fitCyclopsModel(cyclopsData)
coef(cyclopsFit)

# (Estimates in this example will vary due to the random simulation)

OHDSI/EvidenceSynthesis documentation built on Sept. 7, 2024, 12:09 a.m.