Pinlyu3/LRLoop: Two-way communication between cells

In this work, we propose a new method, ligand-receptor loop (LRLoop), which is based on the assumption that cell-cell communications are likely to form closed feedback loops. We assessed our methods in both bulk and single-cell RNA-seq datasets. Our method outperformed other existing methods. We also applied our method to a dataset for retinal development and predicted the cell-cell communications during the early stages of retinal development.

install.packages("remotes")
remotes::install_github("Pinlyu3/LRLoop")