RGLab/COMPASS: Combinatorial Polyfunctionality Analysis of Single Cells

COMPASS is a statistical framework that enables unbiased analysis of antigen-specific T-cell subsets. COMPASS uses a Bayesian hierarchical framework to model all observed cell-subsets and select the most likely to be antigen-specific while regularizing the small cell counts that often arise in multi-parameter space. The model provides a posterior probability of specificity for each cell subset and each sample, which can be used to profile a subject's immune response to external stimuli such as infection or vaccination.

Getting started

Package details

AuthorLynn Lin, Kevin Ushey, Greg Finak, Ravio Kolde (pheatmap)
Bioconductor views FlowCytometry ImmunoOncology
MaintainerGreg Finak <gfinak@fhcrc.org>
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
RGLab/COMPASS documentation built on Feb. 11, 2021, 3:23 p.m.