IncrementsHSRBeta-class | R Documentation |
IncrementsHSRBeta
IncrementsHSRBeta
is a class for limiting further increments using
a Hard Safety Rule based on the Bin-Beta model.
Increment control is based on the number of observed DLTs and number of
subjects at each dose level. The probability of toxicity is calculated
using a Bin-Beta model with prior (a,b). If the probability exceeds
the threshold for a given dose, that dose and all doses above are excluded
from further escalation.
This is a hard safety rule that limits further escalation based on the
observed data per dose level, independent from the underlying model.
IncrementsHSRBeta(target = 0.3, prob = 0.95, a = 1, b = 1)
.DefaultIncrementsHSRBeta()
target |
( |
prob |
( |
a |
( |
b |
( |
target
(proportion
)
the target toxicity, except
0 or 1.
prob
(proportion
)
the threshold probability (except 0 or 1) for
a dose being toxic.
a
(number
)
shape parameter a > 0
of probability distribution
Beta (a,b).
b
(number
)
shape parameter b > 0
of probability distribution
Beta (a,b).
Typically, end users will not use the .DefaultIncrementsHSRBeta()
function.
# Limit the escalation with a hard safety criteria to the doses that are below
# the first dose that is toxic with a probability of 0.95.
my_increments <- IncrementsHSRBeta(target = 0.3, prob = 0.95)
Add the following code to your website.
For more information on customizing the embed code, read Embedding Snippets.