IncrementsRelativeDLT-class | R Documentation |
IncrementsRelativeDLT
IncrementsRelativeDLT
is the class for increments control based on
relative differences in terms of DLTs.
IncrementsRelativeDLT(intervals, increments)
.DefaultIncrementsRelativeDLT()
intervals |
( |
increments |
( |
intervals
(integer
)
a vector with the left bounds of the
relevant DLT intervals. For example, intervals = c(0, 1, 3)
specifies
three intervals (sets of DLTs: first, 0 DLT; second 1 or 2 DLTs; and the third
one, at least 3 DLTs. That means, the right bound of the intervals are
exclusive to the interval and the last interval goes from the last value to
infinity.
increments
(numeric
)
a vector of maximum allowable relative
increments corresponding to intervals
. IT must be of the same length
as the length of intervals
.
This considers all DLTs across all cohorts observed so far.
Typically, end users will not use the .DefaultIncrementsRelativeDLT()
function.
IncrementsRelativeDLTCurrent which only considers the DLTs in the current cohort.
# This is the example of a rule for:
# maximum doubling the dose if no DLTs were observed in the whole study so far
# or maximum increasing the dose by 1.33 if 1 or 2 DLTs were observed so far
# or maximum increasing the dose by 1.22 if 3 or more DLTs were observed so far.
my_increments <- IncrementsRelativeDLT(
intervals = c(0, 1, 3),
increments = c(1, 0.33, 0.2)
)
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