IncrementsRelativeDLTCurrent-class: 'IncrementsRelativeDLTCurrent'

In Roche/crmPack: Object-Oriented Implementation of CRM Designs

IncrementsRelativeDLTCurrent

Description

IncrementsRelativeDLTCurrent is the class for increments control based on relative differences and current DLTs. The class is based on the number of DLTs observed in the current cohort, but not cumulatively over all cohorts so far.

Usage

IncrementsRelativeDLTCurrent(intervals = c(0L, 1L), increments = c(2L, 1L))

.DefaultIncrementsRelativeDLTCurrent()

Arguments

intervals	(numeric) see slot definition.
increments	(numeric) see slot definition.

Note

Typically, end users will not use the .DefaultIncrementsRelativeDLTCurrent() function.

See Also

IncrementsRelativeDLT.

Examples

# As example, here is the rule for:
# maximum doubling the dose if no DLTs were observed at the current dose
# or maximum increasing the dose by 1.33 if 1 or 2 DLTs were observed at the current dose
# or maximum increasing the dose by 1.22 if 3 or more DLTs were observed.

my_increments <- IncrementsRelativeDLTCurrent(
  intervals = c(0, 1, 3),
  increments = c(1, 0.33, 0.2)
)

Roche/crmPack documentation built on April 30, 2024, 3:19 p.m.