LogisticNormalFixedMixture-class: 'LogisticNormalFixedMixture'

In Roche/crmPack: Object-Oriented Implementation of CRM Designs

LogisticNormalFixedMixture

Description

LogisticNormalFixedMixture is the class for standard logistic regression model with fixed mixture of multiple bivariate (log) normal priors on the intercept and slope parameters. The weights of the normal priors are fixed, hence no additional model parameters are introduced. This type of prior is often used to better approximate a given posterior distribution, or when the information is given in terms of a mixture.

Usage

LogisticNormalFixedMixture(components, weights, ref_dose, log_normal = FALSE)

.DefaultLogisticNormalFixedMixture()

Arguments

components	(list) the specifications of the mixture components, a list with ModelParamsNormal objects for each bivariate (log) normal prior.
weights	(numeric) the weights of the components; these must be positive and will be normalized to sum to 1.
ref_dose	(number) the reference dose x* (strictly positive number).
log_normal	(flag) should a log normal prior be specified, such that the mean vectors and covariance matrices are valid for the intercept and log slope?

Details

The covariate is the natural logarithm of the dose x divided by the reference dose x*, i.e.:

logit[p(x)] = alpha0 + alpha1 * log(x/x*),

where p(x) is the probability of observing a DLT for a given dose x. The prior

(alpha0, alpha1) ~ w1 * Normal(mean1, cov1) + ... + wK * Normal(meanK, covK),

if a normal prior is used and

(alpha0, log(alpha1)) ~ w1 * Normal(mean1, cov1) + ... + wK * Normal(meanK, covK),

if a log normal prior is used. The weights w1, ..., wK of the components are fixed and sum to 1.

The slots of this class comprise a list with components parameters. Every single component contains the mean vector and the covariance matrix of bivariate normal distributions. Remaining slots are the weights of the components as well as the reference dose. Moreover, a special indicator slot specifies whether a log normal prior is used.

Slots

components

(list)
the specifications of the mixture components, a list with ModelParamsNormal objects for each bivariate (log) normal prior.

weights

(numeric)
the weights of the components; these must be positive and must sum to 1.

ref_dose

(positive_number)
the reference dose.

log_normal

(flag)
should a log normal prior be used, such that the mean vectors and covariance matrices are valid for the intercept and log slope?

Note

Typically, end-users will not use the .DefaultLogisticNormalFixedMixture() function.

See Also

ModelParamsNormal, ModelLogNormal, LogisticNormalMixture, LogisticLogNormalMixture.

Examples

my_model <- LogisticNormalFixedMixture(
  components = list(
    comp1 = ModelParamsNormal(
      mean = c(-0.85, 1),
      cov = matrix(c(1, -0.5, -0.5, 1), nrow = 2)
    ),
    comp2 = ModelParamsNormal(
      mean = c(1, 1.5),
      cov = matrix(c(1.2, -0.45, -0.45, 0.6), nrow = 2)
    )
  ),
  weights = c(0.3, 0.7),
  ref_dose = 50
)

Roche/crmPack documentation built on April 30, 2024, 3:19 p.m.