NextBestProbMTDLTE-class: 'NextBestProbMTDLTE'

In Roche/crmPack: Object-Oriented Implementation of CRM Designs

NextBestProbMTDLTE

Description

NextBestProbMTDLTE is the class of finding a next best dose that selects the dose with the highest probability of having a toxicity rate less or equal to the toxicity target. The dose is determined by calculating the posterior toxicity probability for each dose per iteration and select the maximum dose that has a toxicity probability below or equal to the target. The dose with the highest frequency of being selected as MTD across iterations is the next best dose. Placebo is not considered in the calculation and removed from the dose grid for any calculations.

Usage

NextBestProbMTDLTE(target)

.DefaultNextBestProbMTDLTE()

Arguments

target

(numeric) see slot definition.

Slots

target

(numeric)
the target toxicity probability.

Note

Typically, end users will not use the .DefaultNextBestProbMTDLTE() function.

Examples

# In the example below, the MTD is defined as the dose with the highest
# probability of having a toxicity rate below 30%.
next_best_prob_mtd_lte <- NextBestProbMTDLTE(target = 0.3)

Roche/crmPack documentation built on April 30, 2024, 3:19 p.m.