NextBestProbMTDMinDist-class: 'NextBestProbMTDMinDist'

In Roche/crmPack: Object-Oriented Implementation of CRM Designs

NextBestProbMTDMinDist

Description

NextBestProbMTDMinDist is the class of finding a next best dose that selects the dose with the highest probability of having a toxicity rate with the smallest distance to the toxicity target. The dose is determined by calculating the posterior toxicity probability for each dose per iteration and select the dose that has the smallest toxicity probability distance to the target. The dose with the highest frequency of being selected as MTD across iterations is the next best dose. Placebo is not considered as the next dose and for that reason not used in calculations. I.e. for placebo the toxicity probability distance to target is not calculated and taken into account for determination of the next dose.

Usage

NextBestProbMTDMinDist(target)

.DefaultNextBestProbMTDMinDist()

Arguments

target

(numeric) see slot definition.

Slots

target

(numeric)
the target toxicity probability.

Note

Typically, end users will not use the .DefaultNextBestProbMTDMinDist() function.

Examples

# In the example below, the MTD is defined as the dose with the highest
# probability of having a toxicity rate with minimal distance
# to the target of 30%.
next_best_prob_mtd_min_dist <- NextBestProbMTDMinDist(target = 0.3)

Roche/crmPack documentation built on April 30, 2024, 3:19 p.m.