RuleDesign-class | R Documentation |
RuleDesign
RuleDesign
is the class for rule-based designs. The difference between
this class and the Design
class is that RuleDesign
does not contain
model
, stopping
and increments
slots.
RuleDesign(nextBest, cohort_size, data, startingDose)
.DefaultRuleDesign()
ThreePlusThreeDesign(doseGrid)
nextBest |
( |
cohort_size |
( |
data |
( |
startingDose |
( |
doseGrid |
( |
ThreePlusThreeDesign()
: creates a new 3+3 design object from a dose grid.
nextBest
(NextBest
)
how to find the next best dose.
cohort_size
(CohortSize
)
rules for the cohort sizes.
data
(Data
)
specifies dose grid, any previous data, etc.
startingDose
(number
)
the starting dose, it must lie on the dose
grid in data
.
Typically, end users will not use the .DefaultRuleDesign()
function.
# Specify the design to run simulations. The design comprises a model,
# the escalation rule, starting data, a cohort size and a starting dose.
# Initialing a 3+3 design with constant cohort size of 3 and starting dose equal 5.
my_design <- RuleDesign(
nextBest = NextBestThreePlusThree(),
cohort_size = CohortSizeConst(size = 3L),
data = Data(doseGrid = c(5, 10, 15, 25, 35, 50, 80)),
startingDose = 5
)
# Initialing a 3+3 design with constant cohort size of 3 and starting dose equal 8.
my_design <- ThreePlusThreeDesign(doseGrid = c(8, 10, 15, 25, 35, 50, 80))
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