RuleDesignOrdinal-class: 'RuleDesignOrdinal'

In Roche/crmPack: Object-Oriented Implementation of CRM Designs

RuleDesignOrdinal

Description

RuleDesignOrdinal is the class for rule-based designs. The difference between this class and the DesignOrdinal class is that RuleDesignOrdinal does not contain model, stopping and increments slots.

Usage

RuleDesignOrdinal(next_best, cohort_size, data, starting_dose)

.DefaultRuleDesignOrdinal()

Arguments

next_best	(NextBestOrdinal) see slot definition.
cohort_size	(CohortSizeOrdinal) see slot definition.
data	(DataOrdinal) see slot definition.
starting_dose	(number) see slot definition.

Slots

next_best

(NextBestOrdinal)
how to find the next best dose.

cohort_size

(CohortSizeOrdinal)
rules for the cohort sizes.

data

(DataOrdinal)
specifies dose grid, any previous data, etc.

starting_dose

(number)
the starting dose, it must lie on the dose grid in data.

Note

Typically, end users will not use the .DefaultRuleDesignOrdinal() function.

Examples

RuleDesignOrdinal(
  next_best = NextBestOrdinal(
    1L,
    NextBestMTD(
      target = 0.25,
      derive = function(x) median(x, na.rm = TRUE)
    )
  ),
  cohort_size = CohortSizeOrdinal(1L, CohortSizeConst(size = 3L)),
  data = DataOrdinal(doseGrid = c(5, 10, 15, 25, 35, 50, 80)),
  starting_dose = 5
)

Roche/crmPack documentation built on April 30, 2024, 3:19 p.m.