StoppingHighestDose-class: 'StoppingHighestDose'

In Roche/crmPack: Object-Oriented Implementation of CRM Designs

StoppingHighestDose

Description

StoppingHighestDose is the class for stopping based on the highest dose. That is, the stopping occurs when the highest dose is reached.

Usage

StoppingHighestDose(report_label = NA_character_)

.DefaultStoppingHighestDose()

Arguments

report_label

(string or NA) see slot definition.

Note

Typically, end users will not use the .DefaultStoppingHighestDose() function.

Examples

# The following stopping rule is met when:
# - next proposed dose is highest dose, and
# - there are already at least 3 patients on that dose, and
# - we are sure that this dose is safe, e.g. the probability to be in (0%, 20%)
# interval of the DLT rate is above 50%.
my_stopping <- StoppingHighestDose() &
  StoppingPatientsNearDose(nPatients = 3, percentage = 0) &
  StoppingTargetProb(target = c(0, 0.2), prob = 0.5)

# We note that this rule would then need to be combined with the other standard
# stopping rules, when the MTD is found based on being near e.g. a 30% DLT
# probability or having reached maximal sample size, in the manner of:
# stop_rule <- stop_high | stop_low | stop_sample_size # nolintr.

Roche/crmPack documentation built on April 30, 2024, 3:19 p.m.