StoppingMTDdistribution-class: 'StoppingMTDdistribution'

In Roche/crmPack: Object-Oriented Implementation of CRM Designs

StoppingMTDdistribution

Description

StoppingMTDdistribution is the class for stopping based on the posterior distribution of the MTD. It is used for the cases where the stopping occurs when the probability of MTD > thresh * next_dose is greater than or equal to prob, where the next_dose is the recommended next best dose. Here, the MTD is defined as the dose that reaches a specific target probability of the occurrence of a DLT.

Usage

StoppingMTDdistribution(
  target = 0.33,
  thresh = 0.5,
  prob = 0.9,
  report_label = NA_character_
)

.DefaultStoppingMTDdistribution()

Arguments

target	(proportion) see slot definition.
thresh	(proportion) see slot definition.
prob	(proportion) see slot definition.
report_label	(string or NA) see slot definition.

Slots

target

(proportion)
the target toxicity probability (except 0 or 1) defining the MTD.

thresh

(proportion)
the threshold (except 0 or 1) relative to the recommended next best dose.

prob

(proportion)
required minimum probability, except 0 or 1.

Note

Typically, end users will not use the .DefaultStoppingMTDDistribution() function.

Examples

# As example, here is the rule for stopping the study if there is at least 0.9
# probability that MTD > 0.5 * next_dose. Here MTD is defined as the dose for
# which prob(DLT) = 0.33
my_stopping <- StoppingMTDdistribution(
  target = 0.33,
  thresh = 0.5,
  prob = 0.9
)

Roche/crmPack documentation built on April 30, 2024, 3:19 p.m.