StoppingMaxGainCIRatio-class: 'StoppingMaxGainCIRatio'

In Roche/crmPack: Object-Oriented Implementation of CRM Designs

StoppingMaxGainCIRatio

Description

StoppingMaxGainCIRatio is the class for testing a stopping rule that is based on a target ratio of the 95% credibility interval. Specifically, this is the ratio of the upper to the lower bound of the 95% credibility interval's estimate of the: (1) target dose (i.e. a dose that corresponds to a given target probability of the occurrence of a DLT prob_target), or (2) max gain dose (i.e. a dose which gives the maximum gain), depending on which one out of these two is smaller.

Usage

StoppingMaxGainCIRatio(
  target_ratio = 5,
  prob_target = 0.3,
  report_label = NA_character_
)

.DefaultStoppingMaxGainCIRatio()

Arguments

target_ratio	(numeric) see slot definition.
prob_target	(proportion) see slot definition.
report_label	(string or NA) see slot definition.

Slots

target_ratio

(numeric)
target for the ratio of the 95% credibility interval's estimate, that is required to stop a trial.

prob_target

(proportion)
the target probability of the occurrence of a DLT.

Examples

# Define the target stopping ratio (5) and the target probability of a DLT to
# be used (0.3).
my_stopping <- StoppingMaxGainCIRatio(target_ratio = 5, prob_target = 0.3)
.DefaultStoppingMaxGainCIRatio()

Roche/crmPack documentation built on April 30, 2024, 3:19 p.m.