StoppingTDCIRatio-class: 'StoppingTDCIRatio'

In Roche/crmPack: Object-Oriented Implementation of CRM Designs

StoppingTDCIRatio

Description

StoppingTDCIRatio is the class for testing a stopping rule that is based on a target ratio of the 95% credibility interval. Specifically, this is the ratio of the upper to the lower bound of the 95% credibility interval's estimate of the target dose (i.e. a dose that corresponds to a given target probability of the occurrence of a DLT prob_target).

Usage

StoppingTDCIRatio(
  target_ratio = 5,
  prob_target = 0.3,
  report_label = NA_character_
)

.DefaultStoppingTDCIRatio()

Arguments

target_ratio	(numeric) see slot definition.
prob_target	(proportion) see slot definition.
report_label	(string or NA) see slot definition.

Slots

target_ratio

(numeric)
target for the ratio of the 95% credibility interval's estimate, that is required to stop a trial.

prob_target

(proportion)
the target probability of the occurrence of a DLT.

Note

Typically, end users will not use the .DefaultStoppingTDCIRatio() function.

Examples

# Define the target stopping ratio (5) and the target probability of a DLT to
# be used (0.3).
my_stopping <- StoppingTDCIRatio(
  target_ratio = 5,
  prob_target = 0.3
)

Roche/crmPack documentation built on April 30, 2024, 3:19 p.m.