StoppingTargetBiomarker-class | R Documentation |
StoppingTargetBiomarker
StoppingTargetBiomarker
is a class for stopping based on probability of
target biomarker.
StoppingTargetBiomarker(
target = c(0.9, 1),
prob = 0.3,
is_relative = TRUE,
report_label = NA_character_
)
.DefaultStoppingTargetBiomarker()
target |
( |
prob |
( |
is_relative |
( |
report_label |
( |
target
(numeric
)
the biomarker target range that needs to be
reached. For example, target = c(0.8, 1.0)
with is_relative = TRUE
means that we target a dose with at least 80% of maximum biomarker level.
is_relative
(flag
)
is target relative? If it so (default), then
the target
is interpreted relative to the maximum, so it must be a
probability range. Otherwise, the target
is interpreted as absolute
biomarker range.
prob
(proportion
)
required target probability (except 0 or 1) for
reaching sufficient precision.
Typically, end users will not use the .DefaultStoppingTargetBiomarker()
function.
# Stopping the study if there is at least 0.5 probability that the biomarker
# (efficacy) is within the biomarker target range of [0.9, 1.0] (relative to the
# maximum for the biomarker).
my_stopping <- StoppingTargetBiomarker(target = c(0.9, 1), prob = 0.5)
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