StoppingTargetProb-class: 'StoppingTargetProb'

In Roche/crmPack: Object-Oriented Implementation of CRM Designs

StoppingTargetProb

Description

StoppingTargetProb is the class for stopping based on the probability of the DLT rate being in the target toxicity interval.

Usage

StoppingTargetProb(
  target = c(0.2, 0.35),
  prob = 0.4,
  report_label = NA_character_
)

.DefaultStoppingTargetProb()

Arguments

target	(number) see slot definition.
prob	(proportion) see slot definition.
report_label	(string or NA) see slot definition.

Slots

target

(number)
the target toxicity interval, e.g. c(0.2, 0.35).

prob

(proportion)
required target toxicity probability (except 0 or 1) for reaching sufficient precision.

Note

Typically, end users will not use the .DefaultStoppingTargetProb() function.

Examples

# As example, here is the rule for stopping the study if the posterior
# probability that [0.2 =< Prob(DLT | dose) <= 0.35] for the next best dose
# is above 0.5.
my_stopping <- StoppingTargetProb(target = c(0.2, 0.35), prob = 0.5)

Roche/crmPack documentation built on April 30, 2024, 3:19 p.m.