h_next_best_mg_doses_at_grid: Get Closest Grid Doses for a Given Target Doses for...

In Roche/crmPack: Object-Oriented Implementation of CRM Designs

Get Closest Grid Doses for a Given Target Doses for nextBest-NextBestMaxGain Method.

Description

Helper function that for a given target doses finds the dose in grid that is closest and below the target. There are four different targets in the context of nextBest-NextBestMaxGain() method: min(`dose_mg`, `dose_target_drt`), dose_mg, dose_target_drt or dose_target_eot.

Usage

h_next_best_mg_doses_at_grid(
  dose_target_drt,
  dose_target_eot,
  dose_mg,
  dose_grid,
  doselimit,
  placebo
)

Arguments

dose_target_drt	(number) target dose estimate during the trial.
dose_target_eot	(number) target dose estimate at the end of the trial.
dose_mg	(number) the dose corresponding to the maximum gain.
dose_grid	(numeric) all possible doses.
doselimit	(number) the maximum allowed next dose.
placebo	(flag) if TRUE the first dose level in the dose_grid is considered as placebo.

Roche/crmPack documentation built on April 30, 2024, 3:19 p.m.