tcplFit: Fit the data with the constant, hill, and gain-loss models

In USEPA/CompTox-ToxCast-tcpl: ToxCast Data Analysis Pipeline

Fit the data with the constant, hill, and gain-loss models

Description

tcplFit fits the constant, hill, and gain-loss models to the given data and returns some summary statistics and the fit parameters in a list.

Usage

tcplFit(
  logc,
  resp,
  bmad,
  force.fit = FALSE,
  bidirectional = FALSE,
  verbose = FALSE,
  ...
)

Arguments

logc	Numeric, log concentration values
resp	Numeric, normalized response values
bmad	Numeric, the baseline median absolute deviation for the entire assay
force.fit	Logical, TRUE indicates to attempt fitting every concentration series
bidirectional	Boolean If TRUE, bidirectional negative data before fitting (default=FALSE) The original version of the code required the data to start at small values and rise, so that negative curves had to be bidirectionalped outside the function, and TOP was always positive. Setting bidirectional to TRUE allows both rising and falling curves
verbose	Boolean If TRUE print warning messages
...	Any other data to be included in list output.

Details

when at least one median value is greater than 3*bmad.

Value

List of summary values and fit parameters for the given data.

See Also

tcplObjCnst, tcplObjHill, tcplObjGnls, constrOptim

Examples

logc <- 1:10
resp <- sapply(1:10, tcplHillVal, ga = 5, tp = 50, gw = 0.5)
params <- tcplFit(logc = logc, resp = resp, bmad = 10)
plot(resp ~ logc)
tcplAddModel(pars = params, modl = "hill")

USEPA/CompTox-ToxCast-tcpl documentation built on April 22, 2024, 12:37 p.m.