DoIntegPPI: Integration of gene expression matrix and PPI network

View source: R/DoIntegPPI.R

DoIntegPPIR Documentation

Integration of gene expression matrix and PPI network


This function finds the common genes between the scRNA-Seq data matrix and the genes present in the PPI network, and constructs the maximally connected subnetwork and reduced expression matrix for the computation of signaling entropy.


DoIntegPPI(exp.m, ppiA.m);



The scRNA-Seq data matrix normalized for library size and log2-transformed with a pseudocount of 1.1


The adjacency matrix of a user-given PPI network with rownames and colnames labeling genes (same gene identifier as in exp.m)


A list of two objects:


Reduced expression matrix with genes in the maximally connected subnetwork.


Adjacency matrix of the maximally connected subnetwork.


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aet21/SCENT documentation built on Aug. 1, 2022, 12:05 p.m.