simulation.params: Main parameters of the simulations

In agaye/ESPRESSO.LD: Power Analysis and Sample Size Calculation for two SNPs in Linkage Disequilibrium

Description

A table with 11 columns: scenario.id, seed.val, numsims, numcases, numcontrols, numsubjects, LD, r.target, RR.5.95, p.val, power

Usage

data(simulation.params)

Format

A table with 11 columns and 1 row for each scenario

scenario.id

The ID of the scenario

seed.val

Seed Value

numsims

Number of runs for each simulation

numcases

Number of cases under binary outcome

numcontrols

Number of controls under binary outcome

numsubjects

Number of subjects under continuous outcome

r.target

Pearson coefficient of correlation for the desired level of LD. The value of this parameter is ignored if the parameter 'LD' is set to its default value 0 (i.e. independence)

RR.5.95

The baseline odds ratio for subjects on 95 percent population centile versus 5 percentile. This parameter reflects the heterogeneity in disease risk arising from determinants that have not been measured or have not been included in the model. If this parameter is set to 10, the implication is that a high risk subject (someone at the upper 95 percent centile of population risk) is, all else being equal, at 10 times the odds of developing disease compared to someone else who is at low risk (individual at the lower 5 percent centile of population risk)

p.val

Cut-off p-value defining statistical significance

power

Desired power

Examples

data(simulation.params)

agaye/ESPRESSO.LD documentation built on May 10, 2019, 7:31 a.m.