tests/testthat/examples_fcn_doc/examples_create.poped.database.R

In andrewhooker/PopED: Population (and Individual) Optimal Experimental Design

## Warfarin example from software comparison in:
## Nyberg et al., "Methods and software tools for design evaluation 
##   for population pharmacokinetics-pharmacodynamics studies", 
##   Br. J. Clin. Pharm., 2014. 

library(PopED)

## find the parameters that are needed to define from the structural model
ff.PK.1.comp.oral.md.CL

## -- parameter definition function 
## -- names match parameters in function ff
sfg <- function(x,a,bpop,b,bocc){
  parameters=c(CL=bpop[1]*exp(b[1]),
               V=bpop[2]*exp(b[2]),
               KA=bpop[3]*exp(b[3]),
               Favail=bpop[4],
               DOSE=a[1])
    return(parameters) 
}

## -- Define initial design  and design space
poped.db <- create.poped.database(
  ff_fun=ff.PK.1.comp.oral.sd.CL,
  fg_fun=sfg,
  fError_fun=feps.prop,
  bpop=c(CL=0.15, V=8, KA=1.0, Favail=1), 
  notfixed_bpop=c(1,1,1,0),
  d=c(CL=0.07, V=0.02, KA=0.6), 
  sigma=0.01,
  groupsize=32,
  xt=c( 0.5,1,2,6,24,36,72,120),
  minxt=0,
  maxxt=120,
  a=70)


## evaluate initial design
evaluate_design(poped.db)