bootstrap_fit_signatures: Bootstrapping function for mmsig

In bachisiozic/mmsig: A Mutational Signature Fitting Tool for Hematological Cancers

Description

Bootstrapping function for mmsig

Usage

bootstrap_fit_signatures(
  samples.muts,
  consigts.defn,
  sigt.profs,
  cos_sim_threshold,
  force_include,
  iterations = 1000
)

Arguments

samples.muts	96 classes mutational profile for all samples
consigts.defn	96 classes mutational profile for mutational signature reference
sigt.profs	which signatures to fit for each sample
cos_sim_threshold	cosine similarity threshold to remove signatures
force_include	vector with the names of signatures to always keep in the final profile of every sample
iterations	number of mutational profiles to draw from the multinomial distribution of each sample

Value

For each mutational signature, returns its relative contribution as point estimate and bootstrapping mean with 95 % CI

bachisiozic/mmsig documentation built on Feb. 16, 2021, 12:03 a.m.