compute_fixed: Multivariate regression with covariance estimate

In bhattacharya-a-bt/isoTWAS: Isoform-level transcriptome-wide association studies

Multivariate regression with covariance estimate

Description

The function trains multivariate lasso with a given covariance estimate

Usage

compute_fixed(X, Y, lam2, Omega, tol.in, maxit.in, silent)

Arguments

X	matrix, design matrix of SNP dosages
Y	matrix, matrix of G isoform expression across columns
lam2	numeric, lambda penalty for LASSO
Omega	matrix, precision matrix of Y
tol.in	numeric, tolerance for objective difference
maxit.in	int, maximum number of iteractions
silent	logical

Value

list of MRCE estimates

bhattacharya-a-bt/isoTWAS documentation built on Jan. 9, 2025, 10:25 p.m.