caravagnalab/basilica: bascule

This packages provides the bascule (Bayesian inference and clustering with mutational signatures and an established catalogue) algorithm to detect single-nucleotide substituion signatures in cancer. bascule provides a full Bayesian formulation based on non-negative matrix factorisation, leveraging a catalogue of known signatures. The tool is specifically developed to detect de novo mutational signatures of any type (SBS, DBS, IDS, ...) that are different from the pre-defined reference catalogue and to perform clustering of samples from all the signature types jointly.

install.packages("remotes")
remotes::install_github("caravagnalab/basilica")