bascule-package: bascule: bascule

In caravagnalab/basilica: bascule

bascule: bascule

Description

This packages provides the bascule (Bayesian inference and clustering with mutational signatures and an established catalogue) algorithm to detect single-nucleotide substituion signatures in cancer. bascule provides a full Bayesian formulation based on non-negative matrix factorisation, leveraging a catalogue of known signatures. The tool is specifically developed to detect de novo mutational signatures of any type (SBS, DBS, IDS, ...) that are different from the pre-defined reference catalogue and to perform clustering of samples from all the signature types jointly.

Author(s)

Maintainer: Elena Buscaroli [e-mail]

Authors:

• Giulio Caravagna [e-mail]

See Also

Useful links:

• https://github.com/caravagnalab/bascule

• https://caravagnalab.github.io/bascule/

caravagnalab/basilica documentation built on June 11, 2025, 10:18 p.m.