sim.intervention: Simulate interventions in a Nested Effects Model

Description Usage Arguments Value Author(s) Examples

View source: R/sim.intervention.R

Description

Simulates a knock-down of a list of network nodes and returns the network nodes and effect reporters, where effects are expected.

Usage

1
sim.intervention(x, int, T=1)

Arguments

x

nem object

int

a character vector of nodes in the network

T

number of time steps to be simulated (only for dynoNEMs)

Value

list with two slots:

Sgenes.effected

effected network nodes (by intervention)

Egenes.effected

most likely effected downstream effect reporters (by intervention)

Egenes.effected.prob

probability of each reporter to be effected by the respective intervention experiment.

Author(s)

Holger Froehlich

Examples

1
2
3
4
   data("BoutrosRNAi2002")
   D <- BoutrosRNAiDiscrete[,9:16]
   res = nem(D, control=set.default.parameters(unique(colnames(D)), para=c(0.13,0.05))) 
   sim.intervention(res, "rel") # simulate knock-down of rel

cbg-ethz/pcNEM documentation built on Sept. 27, 2019, 8:58 a.m.