cbg-ethz/pcNEM: Probabilistic combinatorial nested effects model

The package 'pcnem' allows to reconstruct networks from probabilistically modelled combinatorial perturbations. It takes as input (1.) a set of pathway components, which were perturbed, (2.) a perturbation map defining the perturbation probabilities of each component, and (3.) phenotypic readout of these perturbations (e.g. gene expression, protein expression). The output is a directed acyclic graph representing the phenotypic hierarchy.

Package details

AuthorSumana Srivatsa, Niko Beerenwinkel
Bioconductor views Bioinformatics GraphsAndNetworks Microarray NetworkInference Pathways SystemsBiology
MaintainerSumana Srivatsa <sumana.srivatsa@bsse.ethz.ch>
LicenseGPL (>= 2)
URL http://www.bioconductor.org
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
cbg-ethz/pcNEM documentation built on Sept. 27, 2019, 8:58 a.m.