The package 'pcnem' allows to reconstruct networks from probabilistically modelled combinatorial perturbations. It takes as input (1.) a set of pathway components, which were perturbed, (2.) a perturbation map defining the perturbation probabilities of each component, and (3.) phenotypic readout of these perturbations (e.g. gene expression, protein expression). The output is a directed acyclic graph representing the phenotypic hierarchy.
|Author||Sumana Srivatsa, Niko Beerenwinkel|
|Bioconductor views||Bioinformatics GraphsAndNetworks Microarray NetworkInference Pathways SystemsBiology|
|Maintainer||Sumana Srivatsa <[email protected]>|
|License||GPL (>= 2)|
|Package repository||View on GitHub|
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